Psychoactive substances are natural or synthetic substances that act on the central nervous system and alter mental processes such as mood, perception, cognition, consciousness, and behaviour. These substances may be legally prescribed medications (e.g., pain medications or sedatives), legally available substances such as alcohol or caffeine, or controlled or illicit drugs. Psychoactive substances can be used for medical, social, cultural, or recreational purposes, but some carry risks of misuse, dependence, and health or social harms when used in harmful ways.
Psychoactive Substances
Polysubstance Use Facts
What is polysubstance use? The use of more than one drug, also known as polysubstance use, is common. This includes when two or more are taken together or within a short time period, either intentionally or unintentionally. Intentional...
Strategies to Address Cocaine and Methamphetamine
Presented by Richard Rawson, PhD, Emeritus Professor in the Department of Psychiatry and Biobehavioral Science, UCLA School of Medicine and a Research Professor at the University of Vermont, this presentation provided an overview of the...
UNODC supported delegations from four Central Asian countries in a high-level study tour to the United Kingdom
The UNODC Regional Office for Central Asia (ROCA) together with the UNODC Prevention, Treatment and Rehabilitation Section (PTRS) organized a study tour for high-level representatives, including senior officials, policymakers and substance...
Cocaine Reading List
Cocaine is an addictive stimulant drug that originates from the leaves of the coca plant, which is indigenous to South America. The drug's effects include heightened alertness, attention, and energy, as well as feelings of euphoria and...
Hexahydrocannabinol (HHC) and related substances
Introduction The markets for hexahydrocannabinol (HHC) and related semi-synthetic cannabinoids (SSC) are rapidly evolving areas with relatively limited information currently available. The European situation presented in Section 1 can only...
Responding to stimulant use — developments in treatment
Objective: To better understand current developments in the treatment of stimulant use. Background: Stimulant drugs are second only to cannabis as the most widely used class of illicit drug globally, accounting for 68 million past-year...
Implementing PLAT in Sri Lanka
Psychoactive substance use and substance use disorders (SUDs) remain to be a major problem around the world. Which has a negative effect on global health and social and economic functioning. When we are paying attention to the most...
Early exposure to cannabis and long-lasting consequences in the brain
ISSUP Italy are pleased to present their Webinar on How early exposure to cannabis misshapes the brain and exerts long-lived effects.
Normalisation of Prevention Principles and Practices to Reduce Substance Use Disorders Through an Integrated Dissemination and Implementation Framework
Major research breakthroughs over the past 30 years in the field of substance use prevention have served to: (1) enhance understanding of pharmacological effects on the nervous systems and the health and social consequences of the use of...
New Psychoactive Substances in the Homeless Population: A Cross-Sectional Study in the United Kingdom
Abstract The last few years have seen the emergence of new psychoactive substances among the homeless population, specifically synthetic cannabinoid receptor agonists. The purpose of this study is to investigate the knowledge and...