Brenipatida para los trastornos por uso de sustancias: resumen de la evidencia actual (Septiembre 2026)

Fuente:https://sin-adiccion.blogspot.com/2026/09/brenipatide-brenipatida.html

Dado el estado actual de la evidencia, la brenipatida no debe sustituir a los tratamientos aprobados o recomendados por las guías clínicas para los trastornos por consumo de alcohol, opioides o tabaco fuera del contexto de un ensayo clínico.

References / Referencias

• Cai, M., Choi, T., Xie, Y., & Al-Aly, Z. (2026). Glucagon-like peptide-1 receptor agonists and risk of substance use disorders among US veterans with type 2 diabetes: Cohort study. BMJ, 392, e086886. https://doi.org/10.1136/bmj-2025-086886 [pubmed.ncb...lm.nih.gov]
• Patil, S., Jha, N., & Jha, M. K. (2026). Glucagon-like peptide 1 receptor agonists in substance use disorders: A systematic review of ClinicalTrials.gov. Addictive Behaviors Reports, 23, 100671. https://doi.org/10.1016/j.abrep.2026.100671 [pubmed.ncb...lm.nih.gov]
• Sarma, I., Biswas, K. P., Jagdish, P., Praveen, K., Ahmed, K. A., & Saikia, D. (2026). A systematic review and meta-analysis evaluating the role of GLP-1 receptor agonists in substance use disorders. Cureus, 18(6), e111641. https://doi.org/10.7759/cureus.111641 [pubmed.ncb...lm.nih.gov], [pmc.ncbi.nlm.nih.gov]
• Völker, K. M., Prechtl, B. L. H., Bormann, N. L., & Choi, D. S. (2026). The potential role of GLP-1 receptor agonists in substance use disorders: A systematic review. Frontiers in Pharmacology, 16, 1702448. https://doi.org/10.3389/fphar.2025.1702448 [frontiersin.org], [doaj.org]

Clinical trial records / Registros de ensayos clínicos

• ClinicalTrials.gov. A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder (RENEW-ALC-1; NCT07219966). ClinicalTrials.gov record [clinicaltrials.gov]
• ClinicalTrials.gov. A Study of Brenipatide in Participants With Alcohol Use Disorder (RENEW-ALC-2; NCT07219953). ClinicalTrials.gov record [clinicaltrials.gov]
• ClinicalTrials.gov. A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid Relapse (RENEW-Smk-1; NCT07223840). ClinicalTrials.gov record [clinicaltrials.gov]
• ClinicalTrials.gov. A Study of Brenipatide in Participants With Opioid Use Disorder (RENEW-Op-1; NCT07420283). ClinicalTrials.gov record [clinicaltrials.gov]